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Summary
Researchers have identified the LHPP gene, which interacts with stress and plays a pivotal role in treatment-resistant Major Depressive Disorder (MDD) using an animal model. The study highlights the interaction between genetic risks and environmental factors in the onset of MDD. Increased expression of LHPP worsened depression-like behaviors in stressed mice, but esketamine had a positive effect, unlike traditional antidepressants.
Key Facts
- LHPP exacerbates depression-like behaviors in stress-induced mice models
- Mutations in the LHPP gene might have potential antidepressant effects in humans
- Esketamine alleviated LHPP-induced depression-like behaviors in mice
Source:
Elsevier
Discussion
Major depressive disorder (MDD) has both genetic and environmental influences. A gene called LHPP interacts with stress to aggravate treatment-resistant MDD in an animal model. Notably, esketamine, but not traditional antidepressants, showed positive effects in mitigating LHPP-induced depression-like behaviors.
Personal Opinion
As a psychiatrist, I believe this research is incredibly valuable in shedding light on the neurobiology of treatment-resistant depression. The identification of the LHPP gene as a crucial player in stress-induced depression offers potential therapeutic targets for the treatment of MDD in the future.
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Dr Oliver Sullivan, MD, Cure of Mind