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Neuroscientists identify a small molecule that restores visual function after optic nerve injury

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Traumatic injuries to the brain, spinal wire and optic nerve in the central nervous process (CNS) are the primary cause of disability and the 2nd top trigger of dying all over the world. CNS accidents often final result in a catastrophic reduction of sensory, motor and visual features, which is the most tough dilemma confronted by clinicians and investigation experts. Neuroscientists from Town College of Hong Kong (CityU) just lately recognized and shown a tiny molecule that can efficiently promote nerve regeneration and restore visible capabilities just after optic nerve harm, supplying fantastic hope for sufferers with optic nerve personal injury, such as glaucoma-related eyesight loss.

“There is at present no effective procedure readily available for traumatic injuries to the CNS, so there is an quick will need for possible drug to encourage CNS restore and ultimately obtain whole perform recovery, this kind of as visual purpose, in individuals,” reported Dr Eddie Ma Chi-him, Associate Head and Associate Professor in the Division of Neuroscience and Director of the Laboratory Animal Analysis Device at CityU, who led the research.

Boosting mitochondrial dynamics and motility is essential for thriving axon regeneration

Axons, which are a cable-like composition that extends from neurons (nerve cells), are responsible for transmitting signals amongst neurons and from the brain to muscle tissues and glands. The 1st action for productive axon regeneration is to kind active advancement cones and the activation of a regrowth programme, involving the synthesis and transport of resources to regrow axons. These are all vitality-demanding procedures, which have to have the lively transport of mitochondria (the powerhouse of the mobile) to hurt axons at the distal conclusion.

Wounded neurons thus face exclusive worries that need long-length transportation of mitochondria from the soma (cell entire body) to distal regenerating axons, exactly where axonal mitochondria in grownups are generally stationary and area electrical power use is important for axon regeneration.

A research group led by Dr Ma identified a therapeutic tiny molecule, M1, which can maximize the fusion and motility of mitochondria, resulting in sustained, extensive-length axon regeneration. Regenerated axons elicited neural things to do in concentrate on brain areas and restored visual capabilities inside of 4 to 6 weeks just after optic nerve personal injury in M1-handled mice.

Little molecule M1 promotes mitochondrial dynamics and sustains extensive-length axon regeneration

“Photoreceptors in the eyes [retina] forward visual details to neurons in the retina. To aid the restoration of visual perform soon after harm, the axons of the neurons ought to regenerate through the optic nerve and relay nerve impulses to visible targets in the brain by using the optic nerve for image processing and formation,” explained Dr Ma.

To investigate no matter if M1 could promote extended-length axon regeneration right after CNS injuries, the investigate crew assessed the extent of axon regeneration in M1-addressed mice 4 weeks just after personal injury. Strikingly, most of the regenerating axons of M1-treated mice arrived at 4mm distal to the crush site (i.e. near optic chiasm), even though no regenerating axons have been found in auto-handled manage mice. In M1-dealt with mice, the survival of retinal ganglion cells (RGCs, neurons that transmit visual stimuli from the eye to the brain) was considerably elevated from 19% to 33% four weeks just after optic nerve injury.

“This signifies that the M1 cure sustains long-distance axon regeneration from the optic chiasm, i.e. midway concerning the eyes and concentrate on brain area, to multiple subcortical visual targets in the brain. Regenerated axons elicit neural functions in focus on brain regions and restore visible features right after M1 remedy,” Dr Ma added.

M1 treatment method restores visual operate

To further more examine no matter whether M1 therapy can restore visual function, the study crew gave the M1-dealt with mice a pupillary mild reflex test six weeks just after the optic nerve injuries. They located that the lesioned eyes of M1-taken care of mice restored the pupil constriction response upon blue light illumination to a amount comparable to that of non-lesioned eyes, suggesting that M1 treatment method can restore the pupil constriction reaction soon after optic nerve injuries.

In addition, the research workforce assessed the reaction of the mice to a looming stimulus — a visually induced innate defensive response to prevent predators. The mice ended up positioned into an open chamber with a triangular prism-formed shelter and a speedily increasing overhead-black circle as a looming stimulus, and their freeze and escape behaviours had been noticed. Half of the M1-taken care of mice responded to the stimulus by hiding in a shelter, exhibiting that M1 induced sturdy axon regeneration to reinnervate subcortical visible target brain regions for complete recovery of their visible function.

Probable clinical application of M1 for fixing anxious process personal injury

The seven-12 months-prolonged study highlights the opportunity of a commonly obtainable, non-viral remedy for CNS mend, which builds on the team’s previous analysis on peripheral nerve regeneration utilizing gene therapy.

“This time we utilized the small molecule, M1, to mend the CNS basically by intravitreal injection into the eyes, which is an set up health care method for patients, e.g. for macular degeneration therapy. Thriving restoration of visual features, these kinds of as pupillary light reflex and reaction to looming visual stimuli was observed in M1-treated mice 4 to 6 weeks right after the optic nerve experienced been destroyed,” stated Dr Au Ngan-pan, Investigation Associate in the Office of Neuroscience.

The team is also acquiring an animal product for managing glaucoma-relevant vision loss applying M1 and probably other common eye disorders and vision impairments this kind of as diabetic issues-connected retinopathy, macular degeneration and traumatic optic neuropathy. So, more investigation is warranted to evaluate the potential medical software of M1. “This study breakthrough heralds a new technique that could tackle unmet health-related desires in accelerating purposeful restoration within a limited therapeutic time window right after CNS accidents,” said Dr Ma.

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This document was last updated on August 27, 2023

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Informed Consent for Psychotherapy, Nutritional or Medical Counselling

Introduction:

The purpose of this form is to provide you with information about psychotherapy, nutritional counseling, and medical counseling and to obtain your consent to participate in these treatments. These services involve professional relationships between you and your therapist, nutritionist, and medical doctor to address your emotional, nutritional, and medical needs. This form is intended to give you information that will help you make an informed decision about whether or not to engage in these treatments.

Therapist Qualifications:

Your therapist is a licensed mental health professional who has completed an advanced degree in psychology or a related field and has been trained to provide psychotherapy. Your nutritionist and medical doctor are also licensed professionals with expertise in their respective fields. They are committed to providing you with the highest quality of care possible.

Goals and Objectives:

The goals of psychotherapy are to help you overcome emotional or psychological difficulties that are causing distress in your life. Nutritional counseling aims to support your dietary needs, promote healthy eating habits, and address specific nutritional concerns. Medical counseling focuses on providing you with medical guidance, treatment options, and managing your overall health.

Treatment Methods:

Your therapist will use a variety of treatment methods in psychotherapy, including talk therapy, cognitive-behavioral therapy, psychodynamic therapy, mindfulness techniques, or other approaches. Your nutritionist will provide nutritional education, create personalized meal plans, and offer guidance on making healthy food choices. Your medical doctor will assess your medical history, perform necessary examinations, refer you for lab tests and recommend appropriate medical treatments.

Risks and Benefits:

Psychotherapy, nutritional counseling, and medical counseling can be beneficial in various ways, such as improving your emotional well-being, enhancing your nutrition, and promoting better physical health. However, there are also some risks associated with these treatments. Risks may include experiencing uncomfortable emotions during therapy, potential changes in your relationships, and the possibility of addressing challenging nutritional or medical issues.

Confidentiality:

Your therapist, nutritionist, and medical doctor are committed to protecting your privacy and will keep all information discussed during your sessions confidential, with some exceptions. These exceptions include situations where there is an imminent risk of harm to yourself or others, or where there is a legal obligation to disclose information.

Duration and Frequency of Sessions:

The length and frequency of therapy sessions, nutritional counseling sessions, and medical counseling appointments will depend on your individual needs and goals. Typically, therapy and counseling sessions are scheduled weekly or biweekly and last for approximately 50 minutes. While nutritional counselling appointments last up 45 minutes and medical counseling appointments last up to 30 minutes and their frequency may vary.

Fees and Payment:

Fees are charged on a session-by-session or appointment basis and may be covered by insurance if this is available to you.

For insurance coverage, it is important you understand your insurance policy and coverage. You should forward your detailed invoice from Cure of Mind to your insurance provider and discuss with them whether the services provided by the therapist, nutritionist, and medical doctor are eligible for coverage as per the terms of your insurance plan. 

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By ticking the box “Informed Consent” on the booking form, you acknowledge that you have read and understand the information provided and that you have had the opportunity to read the information about psychotherapy, nutritional counseling, and medical counseling provided on Cure of Mind and to ask questions in our Help Center, or during your first appointment with one of our professionals. You consent to participate in these treatments and understand that you may withdraw your consent at any time.

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